Effect of host response (incorporation, encapsulation, mixed incorporation and encapsulation, or resorption) on the tensile strength of graft-reinforced repair in the rat ventral hernia model

Objective The objective of the study was to determine whether the elicited histologic response to synthetic and xenograft materials affected the tensile strength of mesh-reinforced repairs in the rat ventral hernia model. Study Design Hernias were repaired with Gynemesh, Pelvicol, Pelvisoft, or Surg...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 2007-12, Vol.197 (6), p.638.e1-638.e6
Main Authors: Trabuco, Emanuel C., MD, Zobitz, Mark E., MS, Klingele, Christopher J., MD, MS, Gebhart, John B., MD, MS
Format: Article
Language:English
Subjects:
Abdominal Wall - pathology
Animals
Biocompatible Materials
biomaterial
Bioprosthesis
dermal collagen
Disease Models, Animal
Hernia, Ventral - physiopathology
Hernia, Ventral - surgery
heterologous transplantation
Obstetrics and Gynecology
porcine dermis
Rats
Rats, Wistar
small intestine submucosa
Surgical Mesh
Sutures
Tensile Strength
Wound Healing - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective The objective of the study was to determine whether the elicited histologic response to synthetic and xenograft materials affected the tensile strength of mesh-reinforced repairs in the rat ventral hernia model. Study Design Hernias were repaired with Gynemesh, Pelvicol, Pelvisoft, or Surgisis (representing incorporation, encapsulation, mixed incorporation and encapsulation, or resorption responses) and were compared with a suture-plicated control. Six animals per group were killed at 1 and 3 months after graft implantation. Preimplantation tensile strength was also measured for each graft material and native rat abdominal wall. Results Before implantation, Pelvicol had significantly higher adjusted tensile strength when compared with the rat abdominal wall ( P < .001) or the other graft materials ( P ≤ .05). However, no difference in adjusted tensile strength was observed among the groups at 1 and 3 months after implantation. Conclusion The elicited histologic response did not affect the adjusted tensile strength of xenograft or synthetic mesh-reinforced repairs when compared with suture controls.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2007.08.049