Antifungal activities of azole agents against the Malassezia species

Abstract In this paper, we identified 95 Malassezia isolates by morphological and biochemical criteria and assessed the in vitro activity of fluconazole, itraconazole, ketoconazole and voriconazole by broth microdilution against these species using slightly modified Leeming–Notman medium. The Malass...

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Published in:International journal of antimicrobial agents 2007-03, Vol.29 (3), p.281-284
Main Authors: Miranda, Karla Carvalho, de Araujo, Crystiane Rodrigues, Costa, Carolina Rodrigues, Passos, Xisto Sena, de Fátima Lisboa Fernandes, Orionalda, do Rosário Rodrigues Silva, Maria
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents - pharmacology
Azoles - pharmacology
Biological and medical sciences
Fluconazole - pharmacology
Humans
In vitro susceptibility
In Vitro Techniques
Infectious Disease
Itraconazole - pharmacology
Ketoconazole - pharmacology
Malassezia
Malassezia - drug effects
Malassezia - isolation & purification
Malassezia - pathogenicity
Malassezia species
Medical sciences
Microbial Sensitivity Tests
Modified Leeming–Notman medium
Pharmacology. Drug treatments
Pyrimidines - pharmacology
Tinea Versicolor - drug therapy
Tinea Versicolor - microbiology
Triazoles - pharmacology
Voriconazole
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Summary:Abstract In this paper, we identified 95 Malassezia isolates by morphological and biochemical criteria and assessed the in vitro activity of fluconazole, itraconazole, ketoconazole and voriconazole by broth microdilution against these species using slightly modified Leeming–Notman medium. The Malassezia isolates were identified as M. furfur (74), M. sympodialis (11), M. obtusa (8) and M. globosa (2). The modified Leeming–Notman medium used for susceptibility testing allowed good growth of Malassezia spp. Visual reading of the minimal inhibitory concentration (MIC) was readily achieved until Day 5 of incubation at 32 °C. Although high MIC values of 16 μg/mL for fluconazole were observed in 9.5% of Malassezia isolates, in general these microorganisms were susceptible to all drugs studied. Interestingly, one M. globosa isolate showed high MIC values for voriconazole, itraconazole and fluconazole. For the 95 strains, the MIC ranges were
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2006.09.016