Rising to the challenge of resistance: a case study-based discussion

Abstract Physicians treating patients with lower respiratory tract infections face numerous challenges and treatment decisions. For example, when treating a patient with acute exacerbations of chronic obstructive pulmonary disease (AECOPD), a physician must determine: (1) whether the patient should...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2007-02, Vol.29, p.S11-S16
Main Author: Housset, Bruno
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease, asthma
Drug Resistance, Bacterial
Hospitalization
Humans
Infectious Disease
Medical sciences
Pharmacology. Drug treatments
Pneumology
Pseudomonas aeruginosa
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary Disease, Chronic Obstructive - microbiology
Respiratory tract infection
Respiratory Tract Infections - complications
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - microbiology
Sputum
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Summary:Abstract Physicians treating patients with lower respiratory tract infections face numerous challenges and treatment decisions. For example, when treating a patient with acute exacerbations of chronic obstructive pulmonary disease (AECOPD), a physician must determine: (1) whether the patient should be hospitalised; (2) the cause of the exacerbation; (3) whether bacterial infection is present; and (4) which antibacterial agent should be used (if antibacterial treatment is required). In this article, the key challenges faced by physicians treating patients with AECOPD are described and illustrated using a case study. The impact of antibiotic resistance and other factors influencing a physician's treatment decisions are discussed, and current evidence and guidelines which should inform these decisions are reviewed.
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(07)70005-5