Postinfantile giant‐cell hepatitis associated with ulcerative colitis and autoimmune hepatitis

Postinfantile giant cell hepatitis (PGCH) is rare. It is characterized by the presence of multinucleated giant cells in liver biopsy, and although it has been associated with several etiological agents, in many cases its etiology remains unclear. The case is presented herein of an adult woman with P...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2006-12, Vol.21 (12), p.1863-1864
Main Authors: Anagnostopoulos, George K, Margantinis, George, Tsiakos, Stavros, Kostopoulos, Panagiotis, Grigoriadis, Kyriakos, Arvanitidis, Dimitrios
Format: Article
Language:English
Subjects:
Adult
autoimmune hepatitis
Biological and medical sciences
Biopsy
Cholangiopancreatography, Magnetic Resonance
Colitis, Ulcerative - complications
Colitis, Ulcerative - pathology
Diagnosis, Differential
Female
Gastroenterology. Liver. Pancreas. Abdomen
Giant Cells - pathology
giant‐cell hepatitis
Hepatitis, Autoimmune - complications
Hepatitis, Autoimmune - pathology
Humans
inflammatory bowel disease
Liver - pathology
Medical sciences
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
ulcerative colitis
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Description
Summary:Postinfantile giant cell hepatitis (PGCH) is rare. It is characterized by the presence of multinucleated giant cells in liver biopsy, and although it has been associated with several etiological agents, in many cases its etiology remains unclear. The case is presented herein of an adult woman with PGCH in the setting of ulcerative colitis and autoimmune hepatitis. The presence of autoimmune hepatitis in the patient is consistent and supports the autoimmune pathogenesis of PGCH in a subgroup of patients. Furthermore, this finding, along with others, suggests that PGCH may be included in the list of hepatic complications of inflammatory bowel disease.
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2006.03271.x