First detection of Dobrava hantavirus from a patient with severe haemorrhagic fever with renal syndrome by SYBR Green-based real time RT-PCR

Dobrava hantavirus (DOBV) infection was diagnosed in a previously healthy 46-y-old hunter suffering from severe haemorrhagic fever with renal syndrome (HFRS). Specific IgM antibodies against DOBV were identified by an immunofluorescence assay, while viral nucleic acid was detected by the molecular m...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2007, Vol.39 (10), p.902-906
Main Authors: Jakab, Ferenc, Sebók, Judit, Ferenczi, Emoóke, Horváth, Gyózó, Szúcs, György
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Biological and medical sciences
Fluorescent Dyes
Hantavirus
Hantavirus - classification
Hantavirus - genetics
Hantavirus - immunology
Hantavirus - isolation & purification
Hantavirus Infections - physiopathology
Hantavirus Infections - virology
Hemorrhagic Fever with Renal Syndrome - physiopathology
Hemorrhagic Fever with Renal Syndrome - virology
Human viral diseases
Humans
Immunoglobulin M - blood
Infectious diseases
Lassa fever and arenovirus diseases
Male
Medical sciences
Middle Aged
Organic Chemicals
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction - methods
RNA, Viral - blood
Tropical viral diseases
Viral diseases
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Summary:Dobrava hantavirus (DOBV) infection was diagnosed in a previously healthy 46-y-old hunter suffering from severe haemorrhagic fever with renal syndrome (HFRS). Specific IgM antibodies against DOBV were identified by an immunofluorescence assay, while viral nucleic acid was detected by the molecular method, confirming the diagnosis. Our results reveal an existing risk of DOBV transmission to humans in Hungary.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540701387072