High activity of meropenem against Gram-negative bacteria from a paediatric Intensive Care Unit, 2001–2005

Abstract The susceptibility of Gram-negative bacterial strains ( n = 620) isolated from clinical specimens of children hospitalized in a paediatric Intensive Care Unit between 2001 and 2005 was tested. Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2007-03, Vol.29 (3), p.285-288
Main Authors: Patzer, Jan A, Dzierżanowska, Danuta, Pawińska, Alicja, Turner, Philip J
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins - biosynthesis
beta-Lactamases - biosynthesis
Biological and medical sciences
Child
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae - enzymology
Enterobacteriaceae - isolation & purification
Gram-negative bacteria
Gram-Negative Bacteria - drug effects
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - microbiology
Humans
In Vitro Techniques
Infectious Disease
Intensive Care Unit
Intensive Care Units, Pediatric
Medical sciences
Meropenem
MIC
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Poland
Susceptibility
Thienamycins - pharmacology
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Summary:Abstract The susceptibility of Gram-negative bacterial strains ( n = 620) isolated from clinical specimens of children hospitalized in a paediatric Intensive Care Unit between 2001 and 2005 was tested. Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested isolates, with no observed reduction in activity over 5 years. A decrease in prevalence of extended-spectrum β-lactamase and AmpC β-lactamase producing Enterobacteriaceae from 56.3 to 34.1% was found.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2006.09.012