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High activity of meropenem against Gram-negative bacteria from a paediatric Intensive Care Unit, 2001–2005

Abstract The susceptibility of Gram-negative bacterial strains ( n = 620) isolated from clinical specimens of children hospitalized in a paediatric Intensive Care Unit between 2001 and 2005 was tested. Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested...

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Published in:	International journal of antimicrobial agents 2007-03, Vol.29 (3), p.285-288
Main Authors:	Patzer, Jan A, Dzierżanowska, Danuta, Pawińska, Alicja, Turner, Philip J
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - biosynthesis beta-Lactamases - biosynthesis Biological and medical sciences Child Enterobacteriaceae Enterobacteriaceae - drug effects Enterobacteriaceae - enzymology Enterobacteriaceae - isolation & purification Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Humans In Vitro Techniques Infectious Disease Intensive Care Unit Intensive Care Units, Pediatric Medical sciences Meropenem MIC Microbial Sensitivity Tests Pharmacology. Drug treatments Poland Susceptibility Thienamycins - pharmacology
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description	Abstract The susceptibility of Gram-negative bacterial strains ( n = 620) isolated from clinical specimens of children hospitalized in a paediatric Intensive Care Unit between 2001 and 2005 was tested. Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested isolates, with no observed reduction in activity over 5 years. A decrease in prevalence of extended-spectrum β-lactamase and AmpC β-lactamase producing Enterobacteriaceae from 56.3 to 34.1% was found.
doi_str_mv	10.1016/j.ijantimicag.2006.09.012
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subjects	Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - biosynthesis beta-Lactamases - biosynthesis Biological and medical sciences Child Enterobacteriaceae Enterobacteriaceae - drug effects Enterobacteriaceae - enzymology Enterobacteriaceae - isolation & purification Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Humans In Vitro Techniques Infectious Disease Intensive Care Unit Intensive Care Units, Pediatric Medical sciences Meropenem MIC Microbial Sensitivity Tests Pharmacology. Drug treatments Poland Susceptibility Thienamycins - pharmacology
title	High activity of meropenem against Gram-negative bacteria from a paediatric Intensive Care Unit, 2001–2005
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