Notch signaling in stem cell systems

The Notch signaling pathway is among the most commonly used communication channels in animal cells. Recent studies have demonstrated that this pathway is indispensable for cells in various stages of maturation, including terminal differentiation. One main focus in mammalian studies is the role of No...

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Bibliographic Details
Published in:Stem cells (Dayton, Ohio) Ohio), 2006-11, Vol.24 (11), p.2437-2447
Main Author: Chiba, Shigeru
Format: Article
Language:English
Subjects:
Animals
Blood Vessels - embryology
Blood Vessels - metabolism
Bone Marrow Cells - metabolism
Cell Differentiation
Cell Proliferation
Central Nervous System - embryology
Central Nervous System - metabolism
Hematopoietic Stem Cells - metabolism
Humans
Intestinal Mucosa - cytology
Intestinal Mucosa - metabolism
Muscle, Skeletal - cytology
Muscle, Skeletal - metabolism
Organogenesis - physiology
Receptor, Notch1 - metabolism
Signal Transduction
Skin - embryology
Skin - metabolism
Stem Cells - metabolism
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Summary:The Notch signaling pathway is among the most commonly used communication channels in animal cells. Recent studies have demonstrated that this pathway is indispensable for cells in various stages of maturation, including terminal differentiation. One main focus in mammalian studies is the role of Notch in embryonic and postembryonic stem cell systems. In this review, the roles of Notch signaling in various mammalian stem and early progenitor cells are summarized.
ISSN:1066-5099
DOI:10.1634/stemcells.2005-0661