Antidepressant-Like Effects of Sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae)

The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae) on the forced swimming test, and the central noradrenergic, dopaminergic and serotonergic activities in mice. Our results showed that sarsasapogenin treatment at 12.5, 25 and 50 mg...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2006, Vol.29(11), pp.2304-2306
Main Authors: Ren, Li-Xiang, Luo, Yi-Fan, Li, Xia, Zuo, Dai-Ying, Wu, Ying-Liang
Format: Article
Language:English
Subjects:
Anemarrhena - chemistry
Anemarrhena asphodeloides
Animals
antidepressant activity
Antidepressive Agents - chemistry
Antidepressive Agents - isolation & purification
Antidepressive Agents - pharmacology
Antidepressive Agents, Second-Generation - pharmacology
Behavior, Animal - drug effects
Brain Chemistry - drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical - methods
Exploratory Behavior - drug effects
Fluoxetine - pharmacology
forced swimming
Hippocampus - chemistry
Hippocampus - drug effects
Hydroxyindoleacetic Acid - metabolism
Hypothalamus - chemistry
Hypothalamus - drug effects
Male
Mice
monoamine
monoamine oxidase
Monoamine Oxidase Inhibitors - pharmacology
Motor Activity - drug effects
Norepinephrine - metabolism
Plant Extracts - chemistry
Plant Extracts - pharmacology
sarsasapogenin
Serotonin - metabolism
Spirostans - chemistry
Spirostans - pharmacology
Swimming
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Summary:The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae) on the forced swimming test, and the central noradrenergic, dopaminergic and serotonergic activities in mice. Our results showed that sarsasapogenin treatment at 12.5, 25 and 50 mg/kg (p.o.) for 14 d significantly reduced the duration of immobility in the forced swimming test. These doses that affected the immobile response did not affect locomotor activity. In addition, the neurochemical assays showed that sarsasapogenin produced a marked increase of noradrenaline and serotonin levels at 50 mg/kg in both the hypothalamus and the hippocampus. Moreover, sarsasapogenin showed a monoamine oxidase inhibitory activity in the mouse brain. These findings suggest that the antidepressant activity of sarsasapogenin may involve the central monoaminergic neurotransmitter systems.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.2304