Nuclear Factor of Activated T Cell Mediates Proinflammatory Gene Expression in Response to Mechanotransduction

:  Bone adapts to its environment. Osteoblasts and osteocytes are subject to mechanical load in vivo. It has been shown that osteoblasts alter cytokine expression in response to mechanical loading. However, signal transduction pathways that mediate bone cell response to mechanical stimuli have not b...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2007-11, Vol.1117 (1), p.138-142
Main Authors: CELIL AYDEMIR, AYSE B., LEE, STEPHENIE, WON KIM, DAE, GARDNER, THOMAS R., PRINCE, DANIEL, MOK AHN, JAE, YOUNG-IN LEE, FRANCIS
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - metabolism
Cell Line
Cell Proliferation
Cox2
Cyclooxygenase 2 - metabolism
fluid shear stress
Gene Expression Regulation
Humans
Inflammation
Mice
Models, Biological
NFAT
NFATC Transcription Factors - physiology
Osteoblasts - metabolism
Peptides - chemistry
Signal Transduction
Stress, Mechanical
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Summary::  Bone adapts to its environment. Osteoblasts and osteocytes are subject to mechanical load in vivo. It has been shown that osteoblasts alter cytokine expression in response to mechanical loading. However, signal transduction pathways that mediate bone cell response to mechanical stimuli have not been elucidated. In this study, we report an increase in proinflammatory gene expression in response to fluid shear stress (FSS) in human mesenchymal stem cells (hMSCs) and mouse preosteoblasts. Fluid shear stress (FSS)‐induced effect was blocked by the inhibition of the calcineurin–NFATc1 axis, thus implicating a role for nuclear factor of activated T cells (NFAT) signaling in mechanotransduction.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1402.004