Chemoimmunotherapeutic Approach to Prolonged Survival Time in Combination with Immunization and Glutamic Acid Derivatives with Antitumor Activity in Tumor-Bearing Mice

• Published in: Biological & pharmaceutical bulletin 2007/12/01, Vol.30(12), pp.2334-2339
• Main Authors: Samanta, Soma, Alam, SK. Mahasin, Basu, Soumya, Maji, Tapas, Roy, Dilip Kumar, Jha, Tarun
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - therapeutic use; Antineoplastic Agents, Phytogenic - therapeutic use; cancer; Cancer Vaccines - therapeutic use; Carcinoma, Ehrlich Tumor - drug therapy; Carcinoma, Ehrlich Tumor - therapy; chemoimmunotherapy; Combined Modality Therapy; Etoposide - therapeutic use; Female; Glutamates - chemical synthesis; Glutamates - chemistry; Glutamates - pharmacology; glutamine; Immunization; Immunotherapy; Mice; Structure-Activity Relationship; Survival Analysis; survival time; Swiss Albino mouse; Tissue Extracts - therapeutic use
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.30.2334

Cancer is one of the major causes of death. For cancer, the general conventional treatment and standard of care for clinical oncology remains surgery followed by radiation and/or systemic chemotherapy as deemed appropriate based on the clinical findings. Chemoimmunotherapy is an approach to treat cancer where chemotherapy is given along with immunotherapy. Chemoimmunotherapy may be useful to enhance survival time in cancer by improve immunity of the patients. This approach may enhance the therapeutic efficacy. A comparative study was done to assess the therapeutic efficacy of the whole cell vaccine and the tumor extract with or without combination chemotherapy with the synthesized glutamine and glutamic acid derivatives and analogs as well as the standard drug etoposide against Ehrlich Ascites Carcinoma (EAC) cells in Swiss Albino mice. The study showed promising results with the compound 5-N-n-hexyl-2-(4-iso-butylbenzenesulphonyl)glutamine. The compound when combined with the whole cell vaccine as well as the tumor extract increases the survival time and the therapeutic efficacy which is comparable with that of standard drug etoposide.