Receptor for Advanced Glycation End Products Expression on T Cells Contributes to Antigen-Specific Cellular Expansion In Vivo

Receptor for advanced glycation end products (RAGE) is an activation receptor triggered by inflammatory S100/calgranulins and high mobility group box-1 ligands. We have investigated the importance of RAGE on Ag priming of T cells in murine models in vivo. RAGE is inducibly up-regulated during T cell...

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Published in:The Journal of immunology (1950) 2007-12, Vol.179 (12), p.8051-8058
Main Authors: Moser, Bernhard, Desai, Dharmesh D, Downie, Matthew P, Chen, Yali, Yan, Shi Fang, Herold, Kevan, Schmidt, Ann Marie, Clynes, Raphael
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation
Antigen-Presenting Cells - immunology
Cell Movement
Dendritic Cells - immunology
Lymphocyte Activation
Mice
Mice, Transgenic
Receptor for Advanced Glycation End Products
Receptors, Immunologic - analysis
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
T-Lymphocytes - immunology
Th1 Cells - immunology
Toll-Like Receptors - genetics
Toll-Like Receptors - metabolism
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Summary:Receptor for advanced glycation end products (RAGE) is an activation receptor triggered by inflammatory S100/calgranulins and high mobility group box-1 ligands. We have investigated the importance of RAGE on Ag priming of T cells in murine models in vivo. RAGE is inducibly up-regulated during T cell activation. Transfer of RAGE-deficient OT II T cells into OVA-immunized hosts resulted in reduced proliferative responses that were further diminished in RAGE-deficient recipients. Examination of RAGE-deficient dendritic cells did not reveal functional impairment in Ag presentation, maturation, or migratory capacities. However, RAGE-deficient T cells showed markedly impaired proliferative responses in vitro to nominal and alloantigens, in parallel with decreased production of IFN-gamma and IL-2. These data indicate that RAGE expressed on T cells is required for efficient priming of T cells and elucidate critical roles for RAGE engagement during cognate dendritic cell-T cell interactions.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.179.12.8051