The effects of pentoxifylline on liver regeneration after portal vein ligation in rats

• Published in: Liver international 2007-03, Vol.27 (2), p.274-279
• Main Authors: Kucuktulu, Uzer, Alhan, Etem, Tekelioglu, Yavuz, Ozekin, Aysel
• Format: Article
• Language: English
• Subjects: Adenine Nucleotides - metabolism; Animals; Cell Cycle - drug effects; Cell Proliferation - drug effects; Ligation; Liver - metabolism; Liver - pathology; liver regeneration; Liver Regeneration - drug effects; Male; Mitosis - drug effects; Organ Size - drug effects; pentoxifylline; Pentoxifylline - pharmacology; Portal Vein - surgery; portal vein ligation; Rats; Rats, Sprague-Dawley; Time Factors
• ISSN: 1478-3223; 1478-3231
• DOI: 10.1111/j.1478-3231.2006.01419.x

Aim: To determine the effects of pentoxifylline, a methyl xanthine derivative on hepatic cell production of uninterferred lobe after portal vein branch ligation. Methods: Sixty‐six rats were randomly allocated into 9 groups with 8 rats in PVL groups and 6 rats in sham operation groups. The portal branches of the median and the lateral liver lobes, corresponding to approximately 70% of the liver voluma were ligated in the PVL groups. The control group received 0.9% NaCl solution. The rats in the treatment groups received pentoxypilline at the dose of 50 mg/kg/dy. After 1,2,4 days of portal vein ligation in both PVL and PVNL lobes the levels of adenine nucleotides were determined and flowcytometric analysis of cell cycles were performed. Results: On the first day of portal branch ligation energy charge was significantly lower, in pentoxifylline treated group comparing to pentoxfylline untreated group, both in PVL and PVNL lobes (P