Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study

Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter...

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Bibliographic Details
Published in:Mathematical medicine and biology 2007-03, Vol.24 (1), p.85-109
Main Authors: Stevens, Scott A., Previte, Michelle, Lakin, William D., J.Thakore, Nimish, Penar, Paul L., Hamschin, Brandon
Format: Article
Language:English
Subjects:
Acetazolamide - therapeutic use
Algorithms
cerebrospinal fluid
Cerebrospinal Fluid - physiology
Cerebrospinal Fluid Pressure - physiology
Cerebrovascular Circulation - physiology
Constriction, Pathologic - complications
Constriction, Pathologic - physiopathology
Cranial Sinuses - physiopathology
Humans
idiopathic intracranial hypertension
intracranial pressure
Intracranial Pressure - physiology
lumped-parameter model
Models, Biological
Pressure
Pseudotumor Cerebri - etiology
Pseudotumor Cerebri - physiopathology
Pseudotumor Cerebri - therapy
venous sinus
Ventriculoperitoneal Shunt
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Summary:Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.
ISSN:1477-8599
1477-8602
DOI:10.1093/imammb/dql025