Acute Myeloid Leukemia with Multilineage Dysplasia in Children

We retrospectively surveyed pediatric acute myeloid leukemia (AML) patients with multilineage dysplasia treated with the AML 99 and the Children's Cancer and Leukemia Study Group (CCLSG) AML 9805 protocols. We found only 9 AML patients (2.6%) with multilineage dysplasia among the 341 patients w...

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Bibliographic Details
Published in:International journal of hematology 2007-11, Vol.86 (4), p.358-363
Main Authors: ADACHI, Souichi, MANABE, Atsushi, IMAIZUMI, Masue, TAGA, Takashi, TAWA, Akio, TSURUSAWA, Masahito, KIKUCHI, Akira, MASUNAGA, Atsuko, TSUCHIDA, Masahiro, NAKAHATA, Tatsutoshi
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Cell Lineage
Child
Child, Preschool
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
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Summary:We retrospectively surveyed pediatric acute myeloid leukemia (AML) patients with multilineage dysplasia treated with the AML 99 and the Children's Cancer and Leukemia Study Group (CCLSG) AML 9805 protocols. We found only 9 AML patients (2.6%) with multilineage dysplasia among the 341 patients with newly diagnosed de novo AML. Eight of the 9 patients obtained complete remission (CR) following the intensive AML-oriented treatments. Three of 7 patients who underwent stem cell transplantation were alive in CR for more than 4 years, and the 2 patients treated only with chemotherapy were alive in CR for more than 30 months. We did not identify any particular chromosomal abnormalities or differentiation according to the French-American-British classification in these 9 patients. No reports have described AML with multilineage dysplasia in children, and the incidence of the disease is expected to be very low. We plan to conduct a prospective pathologic review to select cases with this disease entity in the next Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 protocol.
ISSN:0925-5710
1865-3774
DOI:10.1532/IJH97.07025