GATA transcription factors in adrenal development and tumors

Of the six GATA transcription factors, GATA-4 and GATA-6 are expressed in the mouse and human adrenal with distinct developmental profiles. GATA-4 is confined to the fetal cortex, i.e. to the less differentiated proliferating cells, while GATA-6 is expressed both in the fetal and adult adrenal. In v...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2007-02, Vol.265-266, p.17-22
Main Authors: Parviainen, Helka, Kiiveri, Sanne, Bielinska, Malgorzata, Rahman, Nafis, Huhtaniemi, Ilpo T., Wilson, David B., Heikinheimo, Markku
Format: Article
Language:English
Subjects:
Adrenal Cortex Neoplasms - genetics
Adrenal Glands - embryology
Adrenal Glands - metabolism
Adrenocortical Carcinoma - genetics
Animals
GATA Transcription Factors - genetics
GATA Transcription Factors - metabolism
Gene Expression Regulation, Neoplastic
Gonadectomy
Humans
Inhibin
Luteinizing hormone
Metaplasia
Mice
Steroidogenesis
Steroidogenic Factor 1
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Summary:Of the six GATA transcription factors, GATA-4 and GATA-6 are expressed in the mouse and human adrenal with distinct developmental profiles. GATA-4 is confined to the fetal cortex, i.e. to the less differentiated proliferating cells, while GATA-6 is expressed both in the fetal and adult adrenal. In vitro, GATA-4 regulates inhibin-α and steroidogenic factor-1 implicated in normal adrenal function. GATA-6 probably has roles in the development and differentiation of adrenocortical cells, and in the regulation of steroidogenesis. GATA-4 expression is dramatically upregulated and GATA-6 downregulated in gonadotropin dependent mouse adrenocortical tumors. This is accompanied by the appearance of luteinizing hormone receptor (LHR). In vitro, GATA-4 transactivates LHR promoter, and gonadotropins upregulate GATA-4 levels. Human adrenal tumors occasionally express GATA-4, whereas GATA-6 levels are usually lower than normal.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2006.12.033