iNOs expression is stimulated by the major surface protein (rWSP) from Wolbachia bacterial endosymbiont of Dirofilaria immitis following subcutaneous injection in mice

Abstract The bacterial endosymbiont Wolbachia of several species of filarial nematodes plays an important role in the inflammatory pathology of filariasis. Nitric oxide (NO) production has also been implicated in the immune response during filarial infections. Here we present data indicating that a...

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Bibliographic Details
Published in:Parasitology international 2007-03, Vol.56 (1), p.71-75
Main Authors: Morchón, R, Bazzocchi, C, López-Belmonte, J, Martín-Pacho, J.R, Kramer, L.H, Grandi, G, Simón, F
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - biosynthesis
Bacteria
Bacterial Outer Membrane Proteins - immunology
Chaperonin 60 - immunology
Dirofilaria immitis
Dirofilaria immitis - microbiology
Dirofilaria immitis - physiology
Dirofilariasis - immunology
Dirofilariasis - parasitology
Gastroenterology and Hepatology
Immunization
Infectious Disease
Inflammation - immunology
Interferon-gamma - genetics
Interferon-gamma - immunology
Interleukin-10 - genetics
Interleukin-4 - genetics
Mice
Mice, Inbred BALB C
Nematoda
Nitric Oxide - metabolism
Nitric Oxide Synthase Type II - genetics
Nitric Oxide Synthase Type II - metabolism
Recombinant Proteins - immunology
RNA, Messenger
rWSP
Symbiosis
Th1 Cells - immunology
Wolbachia
Wolbachia - immunology
Wolbachia - physiology
Wolbachia bacteria
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Summary:Abstract The bacterial endosymbiont Wolbachia of several species of filarial nematodes plays an important role in the inflammatory pathology of filariasis. Nitric oxide (NO) production has also been implicated in the immune response during filarial infections. Here we present data indicating that a recombinant Wolbachia surface protein (rWSP) induces iNOs mRNA expression and NO production, as well as IFN-γ and a Th1-type antibody response, in inoculated BALB/c mice. This effect is not observed when mice are inoculated with a recombinant heat shock protein from Wolbachia (GroEL).
ISSN:1383-5769
1873-0329
DOI:10.1016/j.parint.2006.10.003