Functional oncocytic adrenocortical carcinoma

We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically t...

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Bibliographic Details
Published in:Endocrine pathology 2007-09, Vol.18 (3), p.187-189
Main Authors: Ali, Abdullah Essa, Raphael, Simon J
Format: Article
Language:English
Subjects:
Adrenal Cortex Neoplasms - diagnosis
Adrenal Cortex Neoplasms - metabolism
Adrenal Cortex Neoplasms - physiopathology
Adrenocortical Carcinoma - diagnosis
Adrenocortical Carcinoma - metabolism
Adrenocortical Carcinoma - physiopathology
Adrenocorticotropic hormone
Adult
Aldosterone
Aldosterone - metabolism
Electron microscopy
Humans
Hydrocortisone
Hydrocortisone - metabolism
Hypokalemia
Male
Malignancy
Oxyphil Cells - pathology
Phenotypes
Tumors
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Summary:We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-007-9000-4