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Functional oncocytic adrenocortical carcinoma

We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically t...

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Published in:	Endocrine pathology 2007-09, Vol.18 (3), p.187-189
Main Authors:	Ali, Abdullah Essa, Raphael, Simon J
Format:	Article
Language:	English
Subjects:	Adrenal Cortex Neoplasms - diagnosis Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - physiopathology Adrenocortical Carcinoma - diagnosis Adrenocortical Carcinoma - metabolism Adrenocortical Carcinoma - physiopathology Adrenocorticotropic hormone Adult Aldosterone Aldosterone - metabolism Electron microscopy Humans Hydrocortisone Hydrocortisone - metabolism Hypokalemia Male Malignancy Oxyphil Cells - pathology Phenotypes Tumors
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container_end_page	189
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container_title	Endocrine pathology
container_volume	18
creator	Ali, Abdullah Essa Raphael, Simon J
description	We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.
doi_str_mv	10.1007/s12022-007-9000-4
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subjects	Adrenal Cortex Neoplasms - diagnosis Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - physiopathology Adrenocortical Carcinoma - diagnosis Adrenocortical Carcinoma - metabolism Adrenocortical Carcinoma - physiopathology Adrenocorticotropic hormone Adult Aldosterone Aldosterone - metabolism Electron microscopy Humans Hydrocortisone Hydrocortisone - metabolism Hypokalemia Male Malignancy Oxyphil Cells - pathology Phenotypes Tumors
title	Functional oncocytic adrenocortical carcinoma
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