Botcinins A, B, C, and D, metabolites produced by Botrytis cinerea, and their antifungal activity against Magnaporthe grisea, a pathogen of rice blast disease

Four new metabolites, botcinins A-D, were isolated from the culture filtrate of a strain of Botrytis cinerea. Their structures were determined by spectroscopic methods, mainly NMR techniques, molecular modeling, and the modified Mosher's method. They exhibited antifungal activities against Magn...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-12, Vol.68 (12), p.1768-1772
Main Authors: Tani, H, Koshino, H, Sakuno, E, Nakajima, H
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
antifungal properties
Biological and medical sciences
blast disease
botcinin
Botrytis - chemistry
Botrytis cinerea
Chemical control
chemical structure
Control
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Fungal plant pathogens
Heterocyclic Compounds, 3-Ring - chemistry
Heterocyclic Compounds, 3-Ring - isolation & purification
Heterocyclic Compounds, 3-Ring - pharmacology
Magnaporthe - drug effects
Magnaporthe grisea
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oryza - microbiology
Oryza sativa
Phytopathology. Animal pests. Plant and forest protection
Plant Diseases - microbiology
plant pathogenic fungi
Pyrones - chemistry
Pyrones - isolation & purification
Pyrones - pharmacology
rice
spectral analysis
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Summary:Four new metabolites, botcinins A-D, were isolated from the culture filtrate of a strain of Botrytis cinerea. Their structures were determined by spectroscopic methods, mainly NMR techniques, molecular modeling, and the modified Mosher's method. They exhibited antifungal activities against Magnaporthegrisea, a pathogen of rice blast disease. Botcinins B and C have a MIC of 12.5 microM, and botcinins A and D are not active below 100 microM.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0503855