Architecture of a Biocompatible Supramolecular Material by Supersaturation-Driven Fabrication of its Fiber Network

The architecture of a biocompatible organogel formed by gelation of a small molecule organic gelator, N-lauroyl-l-glutamic acid di-n-butylamide, in isostearyl alcohol was investigated based on a supersaturation-driven crystallographic mismatch branching mechanism. By controlling the supersaturation...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2005-12, Vol.109 (51), p.24231-24235
Main Authors: Li, Jing-Liang, Liu, Xiang-Yang, Wang, Rong-Yao, Xiong, Jun-Ying
Format: Article
Language:English
Subjects:
Cryoelectron Microscopy
Crystallization
Fatty Alcohols - chemistry
Gels
Glutamates - chemistry
Nanostructures - chemistry
Nanostructures - ultrastructure
Phase Transition
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Summary:The architecture of a biocompatible organogel formed by gelation of a small molecule organic gelator, N-lauroyl-l-glutamic acid di-n-butylamide, in isostearyl alcohol was investigated based on a supersaturation-driven crystallographic mismatch branching mechanism. By controlling the supersaturation of the system, the correlation length that determines the mesh size of the fiber network was finely tuned and the rheological properties of the gel were engineered. This approach is of considerable significance for many gel-based applications, such as controlled release of drugs that requires precise control of the mesh size. A direct cryo-transmission electron microscopy (TEM) imaging technique capable of preserving the network structure was used to visualize its nanostructure.
ISSN:1520-6106
1520-5207
DOI:10.1021/jp054676y