Malaria: a peek at the var variorum

Geneticists encountering the diversity of the malaria parasite's var gene family for the first time often complain that its complexity is a nightmare. A new article by Barry et al . presents the latest and most systematic attempt to date to decipher the var variorum. This important work, combin...

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Bibliographic Details
Published in:Trends in parasitology 2007-12, Vol.23 (12), p.563-565
Main Authors: Chookajorn, Thanat, Costanzo, Marna S, Hartl, Daniel L, Deitsch, Kirk W
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Evolution, Molecular
Gastroenterology and Hepatology
Genes, Protozoan
Genetic Variation
Human protozoal diseases
Humans
Infectious Disease
Infectious diseases
Malaria
Malaria, Falciparum - parasitology
Medical sciences
Parasitic diseases
Plasmodium falciparum - genetics
Protozoal diseases
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Summary:Geneticists encountering the diversity of the malaria parasite's var gene family for the first time often complain that its complexity is a nightmare. A new article by Barry et al . presents the latest and most systematic attempt to date to decipher the var variorum. This important work, combined with other recent articles on var global variation such as that by Kraemer et al ., suggests that only the tip of the var diversity iceberg is currently in view. In this article, we discuss these recent results and provide an overview of current understanding of var diversity.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2007.08.022