Ferrocene-Mediated Proton-Coupled Electron Transfer in a Series of Ferrocifen-Type Breast-Cancer Drug Candidates

A double‐barreled approach: The addition of ferrocene to an antiestrogen drug skeleton was found to induce cytotoxicity towards breast‐cancer cells that are resistant to the common antiestrogen drug. The efficacy of this drug has been related to the proton‐coupled electron transfer observed in the p...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-12, Vol.45 (2), p.285-290
Main Authors: Hillard, Elizabeth, Vessières, Anne, Thouin, Laurent, Jaouen, Gérard, Amatore, Christian
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antitumor agents
Breast Neoplasms - pathology
Cell Proliferation - drug effects
Electrochemistry
electron transfer
Electrons
Ferrous Compounds - chemistry
Ferrous Compounds - pharmacology
hormones
Humans
Hydroxylation
Metallocenes
Molecular Structure
Oxidation-Reduction
Protons
Structure-Activity Relationship
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Summary:A double‐barreled approach: The addition of ferrocene to an antiestrogen drug skeleton was found to induce cytotoxicity towards breast‐cancer cells that are resistant to the common antiestrogen drug. The efficacy of this drug has been related to the proton‐coupled electron transfer observed in the presence of pyridine as a base (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502925