TLR-mediated cell signaling by malaria GPIs

Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses...

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Bibliographic Details
Published in:Trends in parasitology 2007-12, Vol.23 (12), p.596-604
Main Author: Gowda, D. Channe
Format: Article
Language:English
Subjects:
Animals
Gastroenterology and Hepatology
Glycosylphosphatidylinositols - chemistry
Glycosylphosphatidylinositols - immunology
Host-Parasite Interactions - immunology
Host-Parasite Interactions - physiology
Humans
Immunity, Innate
Infectious Disease
Inflammation
Malaria Vaccines
Myeloid Differentiation Factor 88
Plasmodium falciparum
Plasmodium falciparum - metabolism
Receptors, Cell Surface - metabolism
Receptors, Immunologic - metabolism
Signal Transduction
Toll-Like Receptors - metabolism
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Summary:Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses mainly through Toll-like receptor (TLR)2/MyD88-mediated signaling. Knowledge of the parasite–host factors involved in activating and regulating innate immune responses and of the associated signaling mechanisms is likely to provide insights into the modulation of parasite-specific adaptive immunity and offer targets for the development of novel therapeutics or a vaccine for malaria. This article focuses on the malaria GPI-mediated cell-signaling mechanisms.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2007.09.003