Differential effects of simultaneous or sequential administration of paroxetine and WAY-100,635 on ejaculatory behavior

Clinical treatment of depression or anxiety with selective serotonin reuptake inhibitors (SSRIs) often results in delayed ejaculation or anorgasmia. Co-treatment with subtype-selective serotonin receptor antagonists may alter the timing of onset of action and potentiate or reduce sexual side effects...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2005-11, Vol.82 (3), p.427-433
Main Authors: Looney, C., Thor, K.B., Ricca, D., Marson, L.
Format: Article
Language:English
Subjects:
5-HT 1A antagonist
Animals
Biological and medical sciences
Ejaculation
Ejaculation - drug effects
Female
Male
Medical sciences
Neuropharmacology
Paroxetine - administration & dosage
Paroxetine - pharmacology
Pharmacology. Drug treatments
Piperazines - administration & dosage
Piperazines - pharmacology
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Pyridines - administration & dosage
Pyridines - pharmacology
Rat
Rats
Rats, Sprague-Dawley
Selective serotonin reuptake inhibitors
Serotonin
Serotonin Antagonists - administration & dosage
Serotonin Antagonists - pharmacology
Serotonin Uptake Inhibitors - administration & dosage
Serotonin Uptake Inhibitors - pharmacology
Sexual Behavior, Animal - drug effects
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Summary:Clinical treatment of depression or anxiety with selective serotonin reuptake inhibitors (SSRIs) often results in delayed ejaculation or anorgasmia. Co-treatment with subtype-selective serotonin receptor antagonists may alter the timing of onset of action and potentiate or reduce sexual side effects. Sexual behavior in male Sprague–Dawley rats was examined after acute administration of the SSRI, paroxetine and the serotonin 1A antagonist, WAY-100,635. Acute administration of paroxetine alone did not alter male ejaculatory behavior. However, administration of paroxetine plus WAY-100,635 resulted in a significant delay in mounting behavior and increased the time to ejaculation. Simultaneous administration of paroxetine and WAY-100,635 produced a greater delay in initiation of mounting behavior and ejaculation compared to sequential administration of paroxetine followed by WAY-100,635. The differential effect on sexual behavior or addition of specific serotonin receptor antagonists may be relevant for clinical treatment therapies of premature ejaculation.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2005.09.014