EGEETomo: a user-friendly, fault-tolerant and grid-enabled application for 3D reconstruction in electron tomography

• Published in: Bioinformatics 2007-12, Vol.23 (24), p.3391-3393
• Main Authors: Bilbao-Castro, J R, Garcia, I, Fernandez, J J
• Format: Article
• Language: English
• Subjects: Algorithms; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; General aspects; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Internet; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Microscopy, Electron - methods; Software; Tomography - methods
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/btm459

Electron tomography is the leading technique to elucidate the structure of complex biological specimens. Due to the resolution needs, huge reconstructions are required. Grid computing has the potential to face the significant computational demands involved. However, there are a number of key issues, such as stability or difficult user-grid interaction, that currently preclude fully exploitation of its potential. EGEETomo is a user-friendly application that facilitates the interaction with the grid for the non-specialized user and automates job submission and supervision. In addition, EGEETomo is supplied with an automated fault recovery mechanism, which is key to make all the work transparent to the user. EGEETomo significantly accelerates tomographic reconstruction by exploiting the computational resources in the EGEE grid with minimal user intervention. Availability: http://www.ace.ual.es/~jrbcast/EGEETomo.tar.gz Contact: [e-mail] or [e-mail]