Studies into the Anticancer Effects of Selenomethionine against Human Colon Cancer

: Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase‐2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention tria...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-11, Vol.1059 (1), p.26-32
Main Authors: NELSON, MARK A., GOULET, ANNE-CHRISTINE, JACOBS, ELIZABETH T., LANCE, PETER
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
cancer chemoprevention
colon cancer
Colonic Neoplasms - drug therapy
Cyclooxygenase 2 - metabolism
Cyclooxygenase Inhibitors - pharmacology
ERK
Extracellular Signal-Regulated MAP Kinases - metabolism
histone H3
Histones - metabolism
Humans
Models, Biological
Selenium - metabolism
selenomethionine
Selenomethionine - pharmacology
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Summary:: Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase‐2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention strategies with selenium compounds represent a viable option to reduce colon cancer. Here we discuss epidemiologic studies and ongoing clinical trials with selenium. In addition, we discuss preclinical mechanistic studies that provide insights into the biochemical and molecular bases for the anticancer effects of selenomethionine.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1339.016