Enantioselective Preparation of 1,1-Diarylethanes: Aldehydes as Removable Steering Groups for Asymmetric Synthesis

Cut it out! Convenient procedures have been delineated for the synthesis of optically active, functionalized 1,1‐diarylethanes by decarbonylation of β,β‐diarylpropionaldehydes. The process can be conducted as a one‐pot 1,4‐addition/decarbonylation sequence. Aldehydes are used as removable steering g...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2007, Vol.46 (48), p.9331-9334
Main Authors: Fessard, Thomas C, Andrews, Stephen P, Motoyoshi, Hajime, Carreira, Erick M
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
asymmetric synthesis
Boronic Acids - chemistry
cleavage reactions
decarbonylation
diarylethanes
Ethane - analogs & derivatives
Ethane - chemical synthesis
Molecular Structure
synthesis design
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Summary:Cut it out! Convenient procedures have been delineated for the synthesis of optically active, functionalized 1,1‐diarylethanes by decarbonylation of β,β‐diarylpropionaldehydes. The process can be conducted as a one‐pot 1,4‐addition/decarbonylation sequence. Aldehydes are used as removable steering groups in this new strategy for the preparation of optically active building blocks.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200702995