Attenuation of Hypotension using Phenylephrine during induction of anaesthesia with Propofol

To observe if phenylephrine mixed with propofol can attenuate hypotensive effects of propofol during induction of anaesthesia. A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2007-11, Vol.57 (11), p.543-547
Main Authors: IMRAN, Muhammad, FAZAL HAMEED KHAN, MANSOOR AHMED KHAN
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anesthetics, Intravenous - pharmacology
Anesthetics, Intravenous - therapeutic use
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiotonic Agents - pharmacology
Cardiotonic Agents - therapeutic use
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
General aspects
Humans
Hypotension - diagnosis
Hypotension - etiology
Hypotension - prevention & control
Incidence
Male
Medical sciences
Middle Aged
Phenylephrine - pharmacology
Phenylephrine - therapeutic use
Propofol - pharmacology
Propofol - therapeutic use
Risk Factors
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Summary:To observe if phenylephrine mixed with propofol can attenuate hypotensive effects of propofol during induction of anaesthesia. A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (control group) patients received propofol mixed with 2cc of 0.9% normal saline. Group B (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 25 microg/cc (total 50 microg); Group C (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 50 microg/cc (total 100 microg). Haemodynamic variables like systolic, diastolic, mean arterial blood pressure and heart rate were noted. Hypotension was defined as 20% decrease in baseline systolic blood pressure recorded before induction of anaesthesia. Phenylephrine in a dose of 100 micrograms attenuated the drop in systolic blood pressure. However phenylephrine in a dose 50 micrograms did not effectively prevent anticipated drop in SBP. Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol.
ISSN:0030-9982