Therapeutic impact of 18FDG-PET/CT in the management of iodine-negative recurrence of differentiated thyroid carcinoma

18-F-fluoro-2-deoxyglucose positron emission tomography ( 18FDG-PET) is useful in the detection of iodine-negative differentiated thyroid carcinoma (DTC). The aim of this prospective study was to assess therapeutic impact of 18FDG-PET imaging using a PET/computed tomography (CT) system in patients w...

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Bibliographic Details
Published in:Surgery 2007-12, Vol.142 (6), p.952-958
Main Authors: Mirallié, Eric, Guillan, Thomas, Bridji, Boumédiene, Resche, Isabelle, Rousseau, Caroline, Ansquer, Catherine, Bodet-Milin, Caroline, Curtet, Chantal, Carnaille, Bruno, Murat, Arnaud, Charbonnel, Bernard, Kraeber-Bodéré, Françoise
Format: Article
Language:English
Subjects:
Adenocarcinoma, Follicular - diagnostic imaging
Adenocarcinoma, Follicular - surgery
Adenoma, Oxyphilic - diagnostic imaging
Adenoma, Oxyphilic - surgery
Adolescent
Adult
Aged
Aged, 80 and over
Cell Differentiation
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoplasm Recurrence, Local - diagnostic imaging
Patient Selection
Positron-Emission Tomography - methods
Prospective Studies
Radiopharmaceuticals
Thyroglobulin - blood
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - surgery
Thyroidectomy
Tomography, X-Ray Computed
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Summary:18-F-fluoro-2-deoxyglucose positron emission tomography ( 18FDG-PET) is useful in the detection of iodine-negative differentiated thyroid carcinoma (DTC). The aim of this prospective study was to assess therapeutic impact of 18FDG-PET imaging using a PET/computed tomography (CT) system in patients with iodine-negative recurrence of DTC. From 2002 to 2006, patients with recurrence of DTC diagnosed by elevated thyroglobulin level and negative 131-I whole-body scan were included. Forty-five patients (31 women, 14 men), with a mean age of 55 years, with 36 papillary, 5 follicular, and 4 Hürthle carcinomas, were studied. All patients had previously undergone total thyroidectomy and postoperative thyroid remnant ablation with 131-I. The findings of 18FDG-PET/CT were positive in 31 patients (68.8%) and negative in 14 (32.2%). Results were true positive in 24 of 31 patients. The sensitivity, positive predictive value, and accuracy of 18FDG-PET/CT were 63%, 77%, and 53%, respectively. Twenty patients were operated on, 19 had neck surgery with mediastinal lymph node dissection (1 case) and lung resection (1 case), and 1 underwent lung resection. Seven patients had a stimulated thyroglobulin level
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2007.09.015