The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing–remitting multiple sclerosis

Abstract In this study we observed higher serum leptin levels in relapsing–remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and...

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Bibliographic Details
Published in:Journal of neuroimmunology 2007-12, Vol.192 (1), p.174-183
Main Authors: Frisullo, Giovanni, Mirabella, Massimiliano, Angelucci, Francesco, Caggiula, Marcella, Morosetti, Roberta, Sancricca, Cristina, Patanella, Agata Katia, Nociti, Viviana, Iorio, Raffaele, Bianco, Assunta, Tomassini, Valentina, Pozzilli, Carlo, Tonali, Pietro Attilio, Matarese, Giuseppe, Batocchi, Anna Paola
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Bacterial Toxins - metabolism
Case-Control Studies
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - metabolism
Cytokines - metabolism
Female
Flow Cytometry - methods
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
Heat-Shock Proteins - metabolism
Hemolysin Proteins - metabolism
Humans
Leptin
Leptin - administration & dosage
Leptin - blood
Male
Middle Aged
Monocytes - metabolism
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - blood
Multiple Sclerosis, Relapsing-Remitting - pathology
Neurology
Radioimmunoassay - methods
Receptors, Leptin - metabolism
Sex Factors
SOCS3
STAT3
STAT3 Transcription Factor - metabolism
Transcription factors
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Summary:Abstract In this study we observed higher serum leptin levels in relapsing–remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2007.08.008