Living Donor Renal Transplantation: Prognostic Factors on Graft Survival

Living donor renal transplantation is a treatment option for patients on dialysis in view of the ever-growing transplantation waiting lists and the stagnation in the number of deceased donors. The objectives of this study were to provide retrospective review of our living donor kidney transplantatio...

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Bibliographic Details
Published in:Transplantation proceedings 2005-11, Vol.37 (9), p.3679-3681
Main Authors: Cacho, D.T., Piqué, A.A., Cusi, L.I.P., Reyes, L.I., Salinas, F.O., del Pozo, R.G.
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Survival - physiology
Humans
Kidney Transplantation - physiology
Living Donors
Male
Medical sciences
Middle Aged
Nuclear Family
Prognosis
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
Tissue, organ and graft immunology
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Summary:Living donor renal transplantation is a treatment option for patients on dialysis in view of the ever-growing transplantation waiting lists and the stagnation in the number of deceased donors. The objectives of this study were to provide retrospective review of our living donor kidney transplantation series (1978–2003) and analysis of graft survival prognostic factors. Among 121 living donor transplantations, the donor mean age was 50.9 years (SD, 1.53) and recipient mean age was 30.4 years (SD, 1.4). Eighty-eight percent of donors were women, 90% were related: siblings 21%, parents 69%, and spouses 6.6%. Kidney failure was of nephrological etiology in 65% of patients and urologic in 15.6%. Eighty-four percent were primary grafts and 16% were second ones. Also, 66.7% of kidneys were placed in the iliac fossa and the rest were left orthotopic approaches. Other analyzed variables included donor gender, acute rejection episodes (ARE), creatinine levels at 1 and 6 months, hypertension (HT), and pediatric recipients. Univariate analysis (Kaplan-Meier) showed that, in patients suffering from ARE or not, the mean graft survival was 7.5 and 15 years, respectively ( P
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2005.10.071