Treatment of Short Gut Syndrome With Early Living Related Small Bowel Transplantation

• Published in: Transplantation proceedings 2005-12, Vol.37 (10), p.4461-4463
• Main Authors: Wang, S.F., Che, X.M., Chen, J.C., Lu, S.Y., Fan, L., Wang, R., Li, G.W.
• Format: Article
• Language: English
• Subjects: Adolescent; Antibiotic Prophylaxis; Biological and medical sciences; Drug Therapy, Combination; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Ileum - blood supply; Ileum - surgery; Immunosuppressive Agents - therapeutic use; Living Donors; Male; Medical sciences; Necrosis; Other diseases. Semiology; Short Bowel Syndrome - pathology; Short Bowel Syndrome - surgery; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue and Organ Harvesting - methods; Tissue, organ and graft immunology; Treatment Outcome; Vena Cava, Inferior - surgery
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2005.10.092

To investigate the results of treating short bowel syndrome with an early living related small bowel transplantation (SBT). A 17-year-old boy with a 20-cm-long residual intestine due to necrotic volvulus received an early living related SBT from his mother. Donor-specific blood transfusion was performed for 8 weeks before transplantation, each time for 50 mL every week. Cytomegalovirus status in both donor and recipient was negative. A 160-cm distal ileal segment was removed from the donor. The graft ilecolic artery and vein were anastomosed to the recipient’s infrarenal aorta and caval vein. The proximal end of the graft was anastomosed end-to-end to the residual recipient jejunum; the distal anastomosis, between the distal end of the graft and transverse colon. An ileostomy was also performed. Immunosuppression, infection prophylaxis, and antithrombotic and nutrition support were given postoperatively. The donor had an uneventful recovery. No technical complications were observed. The recipient was alive and well at 31 weeks after the operation. No graft rejection or infection was observed. He was off TPN 8 weeks after the operation and took low-fat food. The D-xylose test in the recipient was almost normal. Early living related small intestine transplantation is a good treatment for short bowel syndrome.