Synthesis and Properties of Pyrrolidine-Based Negatively Charged Dna Mimics

A set of novel chiral pyrrolidine-based nucleotide mimics, in which nucleobase, hydroxyl group and phosphonic acid residue were attached to different carbon atoms of the pyrrolidine ring, was synthesized. These monomers were used for the synthesis of the corresponding oligomers, and their physico-ch...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2007-01, Vol.26 (10-12), p.1595-1599
Main Authors: Efimov, Vladimir A., Klykov, Valeryi N., Chakhmakhcheva, Oksana G.
Format: Article
Language:English
Subjects:
antisense reagents
DNA - chemistry
DNA mimics
hybridization
Molecular Mimicry
Nucleotides - chemical synthesis
Nucleotides - chemistry
pyrrolidine
Pyrrolidines - chemistry
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Summary:A set of novel chiral pyrrolidine-based nucleotide mimics, in which nucleobase, hydroxyl group and phosphonic acid residue were attached to different carbon atoms of the pyrrolidine ring, was synthesized. These monomers were used for the synthesis of the corresponding oligomers, and their physico-chemical properties were evaluated.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770701548345