Evidence for cycle-dependent expression of follicle-stimulating hormone receptor in human endometrium

Objective. It was the purpose of the present study to investigate whether human endometrium expresses follicle-stimulating hormone (FSH) receptor mRNA and peptide, and whether this expression is regulated in a cycle-dependent manner in endometrium derived from various phases of the menstrual cycle....

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Published in:Gynecological endocrinology 2005-12, Vol.21 (6), p.303-306
Main Authors: La Marca, Antonio, Carducci Artenisio, Alfredo, Stabile, Gaspare, Rivasi, Francesco, Volpe, Annibale
Format: Article
Language:English
Subjects:
Adult
endometrium
Endometrium - metabolism
Female
Follicle-stimulating hormone (FSH)
Follicular Phase - metabolism
FSH receptor
FSH receptor mRNA
Humans
Hysterectomy
Hysteroscopy
immunohistochemistry
Leiomyoma - metabolism
Leiomyoma - surgery
Luteal Phase - metabolism
Menstrual Cycle - metabolism
Middle Aged
Receptors, FSH - biosynthesis
reverse transcription-polymerase chain reaction
Uterine Neoplasms - metabolism
Uterine Neoplasms - surgery
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Summary:Objective. It was the purpose of the present study to investigate whether human endometrium expresses follicle-stimulating hormone (FSH) receptor mRNA and peptide, and whether this expression is regulated in a cycle-dependent manner in endometrium derived from various phases of the menstrual cycle. Methods. FSH receptor mRNA and peptide expression were evaluated by reverse transcription-polymerase chain reaction and by immunohistochemistry in endometrium from 15 women undergoing hysteroscopy to evaluate the morphology of the uterine cavity or hysterectomy for leiomyomas. Results. FSH receptor mRNA was expressed by human endometrium, and its peptide was located immunohistochemically in both proliferative and secretory endometrial epithelial and stromal cells. A significant increase in immunoreactive FSH receptor was observed during the secretory phase. Conclusions. We have shown the presence of FSH receptor in human endometrium and demonstrated that FSH receptor immunostaining is upregulated in the secretory phase of the menstrual cycle. The dynamic pattern of receptor expression indicates that FSH may play a role in the regulation of endometrial function and possibly in the embryo-endometrium interaction.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590500402756