Total ghrelin levels during acute insulin infusion in patients with polycystic ovary syndrome

Controversial data were reported concerning fasting ghrelin (decreased, normal or elevated) in polycystic ovary syndrome (PCOS). The aim of our study was to clarify ghrelin levels in non-obese, overweight, and obese PCOS patients; to investigate the effect of acute insulin infusion on ghrelin in PCO...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2007-11, Vol.30 (10), p.820-827
Main Authors: Micic, D, Sumarac-Dumanovic, M, Kendereski, A, Cvijovic, G, Zoric, S, Pejkovic, D, Micic, J, Milic, N, Dieguez, C, Casanueva, F F
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Body Mass Index
Fasting
Female
Ghrelin - blood
Glucose Clamp Technique
Humans
Hyperinsulinism - blood
Hypoglycemic Agents - administration & dosage
Insulin - administration & dosage
Insulin Resistance
Obesity - blood
Overweight - blood
Polycystic Ovary Syndrome - blood
Sex Hormone-Binding Globulin - metabolism
Testosterone - blood
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Summary:Controversial data were reported concerning fasting ghrelin (decreased, normal or elevated) in polycystic ovary syndrome (PCOS). The aim of our study was to clarify ghrelin levels in non-obese, overweight, and obese PCOS patients; to investigate the effect of acute insulin infusion on ghrelin in PCOS as a chronic insulin-resistant state, with and without the impact of obesity, and to examine ghrelin-androgen interaction. In that order, we evaluated 1) ghrelin levels among 8 nonobese patients with PCOS [body mass index (BMI): 20.52+/-1.31 kg/m2], 8 overweight and obese patients with PCOS (BMI: 34.36+/-6.53 kg/m2) and their respective controls, 2) ghrelin suppression during euglycemic hyperinsulinemic clamp, and 3) ghrelin-androgen interrelationship. After overnight fast, 2-h euglycemic hyperinsulinemic clamp, was performed in all investigated women. Fasting ghrelin was significantly lower in non-obese PCOS than in controls (64.74+/-25.69 vs 108.36+/-52.60; p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03349222