A study of autologous melanocyte transfer in treatment of stable vitiligo

Background: Replenishing melanocytes selectively in vitiliginous macules by autologous melanocytes is a promising treatment. With expertise in culturing melanocytes, it has now become possible to treat larger recipient areas with smaller skin samples. Aim: To study the extent of repigmentation after...

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Published in:Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2005-11, Vol.71 (6), p.393-397
Main Author: Pandya Vishvabhavan, Parmar KirtiS, Shah BelaJ, Bilimoria FE
Format: Article
Language:English
Subjects:
Adult
Autologous melanocyte transplantation, Melanocyte culture, Melanocyte rich cell suspension
Care and treatment
Cell Separation - methods
Cells, Cultured
Female
Health aspects
Humans
Male
Melanocytes
Melanocytes - transplantation
Skin Transplantation
Transplantation, Autologous
Treatment Outcome
Vitiligo
Vitiligo - surgery
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Summary:Background: Replenishing melanocytes selectively in vitiliginous macules by autologous melanocytes is a promising treatment. With expertise in culturing melanocytes, it has now become possible to treat larger recipient areas with smaller skin samples. Aim: To study the extent of repigmentation after autologous melanocyte transplantation in patients with stable vitiligo. Methods: The melanocytes were harvested as an autologous melanocyte rich cell suspension from a donor split thickness graft. Melanocyte culture was performed in selected cases where the melanocyte cell count was insufficient to meet the requirement of the recipient area. These cells were then transplanted to the recipient area that had been superficially dermabraded. Results: An excellent response was seen in 52.17% cases with the autologous melanocyte rich cell suspension (AMRCS) technique and in 50% with the melanocyte culture (MC) technique. Conclusion: Autologous melanocyte transplantation can be an effective form of surgical treatment in stable but recalcitrant lesions of vitiligo.
ISSN:0378-6323
1998-3611
DOI:10.4103/0378-6323.18942