A comparison of two citrate anticoagulation regimens for continuous veno-venous hemofiltration

To assess the safety and efficacy of two different commercial citrate containing pre-filter replacement fluids during continuous veno-venous hemofiltration (CVVH) in patients with frequent filter clotting. Four intensive care units. Sixty-three critically ill patients with acute renal failure (ARF)....

Full description

Saved in:
Bibliographic Details
Published in:International journal of artificial organs 2005-12, Vol.28 (12), p.1211-1218
Main Authors: Egi, M, Naka, T, Bellomo, R, Cole, L, French, C, Trethewy, C, Wan, L, Langenberg, C C, Fealy, N, Baldwin, I
Format: Article
Language:English
Subjects:
Acute Kidney Injury - therapy
Aged
Anticoagulants - therapeutic use
Chi-Square Distribution
Citrates - therapeutic use
Critical Illness
Dialysis Solutions - therapeutic use
Female
Hemofiltration - methods
Humans
Male
Middle Aged
Prospective Studies
Statistics, Nonparametric
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess the safety and efficacy of two different commercial citrate containing pre-filter replacement fluids during continuous veno-venous hemofiltration (CVVH) in patients with frequent filter clotting. Four intensive care units. Sixty-three critically ill patients with acute renal failure (ARF). Prospective observational study. We used a commercial citrate fluid (citrate: 11 mmol/L -fluid A) as predilution replacement for CVVH. We then changed to a new commercial citrate fluid (citrate: 14 mmol/L-fluid B) as replacement fluid and performed statistical comparisons. Replacement fluid rate was fixed at 2,000 ml/hour. Filter life was 12.2 hour with fluid A compared with 17.1 hour with fluid B on average (p=0.0001). Mean post filter ionized calcium concentration was 0.52 mmol/L with fluid A compared with 0.40 mmol/L with fluid B (p
ISSN:0391-3988
1724-6040
DOI:10.1177/039139880502801203