Association of HLA‐DQA1 and DQB1 genes with vitiligo in Chinese Hans

Background  Vitiligo is an acquired depigmentary disorder of the skin and hair which results from selective destruction of melanocytes. Serological typing and genotyping of human leukocyte antigen (HLA) have shown discrepancies in HLA associations with vitiligo in different ethnic populations. Metho...

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Published in:International journal of dermatology 2005-12, Vol.44 (12), p.1022-1027
Main Authors: Yang, Sen, Wang, Ji‐Yun, Gao, Min, Liu, Hong‐Sheng, Sun, Liang‐Dan, He, Ping‐Ping, Liu, Jiang‐Bo, Zhang, An‐Ping, Cui, Yong, Liang, Yan‐Hua, Wang, Zai‐Xing, Zhang, Xue‐Jun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alleles
Child
Child, Preschool
Female
Gene Frequency
HLA-DQ alpha-Chains
HLA-DQ Antigens - classification
HLA-DQ Antigens - genetics
HLA-DQ beta-Chains
Humans
Infant
Male
Middle Aged
Odds Ratio
Vitiligo - genetics
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Summary:Background  Vitiligo is an acquired depigmentary disorder of the skin and hair which results from selective destruction of melanocytes. Serological typing and genotyping of human leukocyte antigen (HLA) have shown discrepancies in HLA associations with vitiligo in different ethnic populations. Methods  Polymerase chain reaction sequence‐specific primer (PCR‐SSP) method was used to analyze the distribution of HLA‐DQA1 and ‐DQB1 alleles among 187 patients with vitiligo and 273 healthy controls through Epi Info version 6 package (Centers for Disease Control and Prevention, Atlanta, GA, USA). Results  The frequencies of HLA‐DQA1*0302 (OR = 1.98, Pc 
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4632.2004.02389.x