Histological study of granulated metrial gland (GMC) cells in beige (DA-bg/bg) rats

To clarify the roles of granulated metrial gland (GMG) cells for successful pregnancy in rats, GMG cells in beige rats (genotype: DA-bg/bg), whose NK cells show lysosomal dysfunction because of abnormalities in cytoplasmic granules, were examined in mid- and late-pregnancy by light and electron micr...

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Bibliographic Details
Published in:Journal of Reproduction and Development 2005, Vol.51(6), pp.799-803
Main Authors: Hondo, E.(Yamaguchi Univ. (Japan)), Kokubo, K, Nagahisa, A, Nakamuta, N, Ozaki, K, Sagara, E, Kiso, Y
Format: Article
Language:English
Subjects:
Animals
Beige rat
Cell Differentiation
CELLS
CELLULE
CELULAS
Cytoplasmic Granules - pathology
Cytoplasmic Granules - ultrastructure
Female
GENE
GENES
GESTATION PERIOD
Granulated metrial gland (GMG) cell
LINFOCITOS
LYMPHOCYTE
LYMPHOCYTES
Lysosomes - pathology
Lysosomes - ultrastructure
Metrial Gland - pathology
Metrial Gland - ultrastructure
MICROSCOPIA
MICROSCOPIE
MICROSCOPY
Microscopy, Electron
PERFORMANCE DE REPRODUCTION
PERIODE DE GESTATION
PERIODO DE GESTACION
Pregnancy
Proteins - genetics
RAT
RATA
RATS
Rats, Mutant Strains
Reproduction - physiology
REPRODUCTIVE PERFORMANCE
REPRODUCTIVIDAD
UTERO
UTERUS
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Summary:To clarify the roles of granulated metrial gland (GMG) cells for successful pregnancy in rats, GMG cells in beige rats (genotype: DA-bg/bg), whose NK cells show lysosomal dysfunction because of abnormalities in cytoplasmic granules, were examined in mid- and late-pregnancy by light and electron microscopies. The GMG cells of beige rats were significantly less in number than those of the two controls (genotypes: DA-bg/+ and DA-+1+) in mid- and late-pregnancy, and this accompanied a 10w reproductive performance in the beige rats. The size of intracellular granules in the GMG cells of the beige rats was larger than for the two controls on each corresponding day of pregnancy. These results suggest that the activity of rat GMG cells and peripheral NK cells might be influenced by the beige gene, which is involved in reproductive performance.
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.17048