New Modes of Translational Control in Development, Behavior, and Disease

Over the last 10 years, the field of translational control has been enriched by atomic resolution structures of ribosomal complexes and factors in different functional states, and increased in sophistication by wedding genetics, reconstituted systems, and structural biology to elucidate basic reacti...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cell 2007-12, Vol.28 (5), p.721-729
Main Authors: Sonenberg, Nahum, Hinnebusch, Alan G.
Format: Article
Language:English
Subjects:
Animals
Disease
Embryonic Development - physiology
Genetics, Behavioral
Protein Biosynthesis - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the last 10 years, the field of translational control has been enriched by atomic resolution structures of ribosomal complexes and factors in different functional states, and increased in sophistication by wedding genetics, reconstituted systems, and structural biology to elucidate basic reactions and mRNA-specific control mechanisms. New regulatory principles have emerged, including repression by micro-RNAs (miRNAs) and mRNA sequestration in cytoplasmic granules, and the field has extended its reach into development, brain function, and human disease. Here we seek to highlight some of the exciting developments of the last decade from the perspectives of our own approaches and expertise; accordingly, many highly noteworthy achievements could not be mentioned and we refer interested readers to the numerous excellent reviews cited below.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2007.11.018