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Impact of androgens on fertility – physiological, clinical and therapeutic aspects

Ovarian androgen synthesis and regulation are essential to ensure adequate steroidogenesis and folliculogenesis. In primates, there is evidence for a direct impact on the number of small antral follicles and on the process of chronic anovulation. Therefore, serum androgen should be more carefully as...

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Published in:	Reproductive biomedicine online 2005-11, Vol.11 (5), p.570-580
Main Authors:	Hugues, J-N, Durnerin, I Cédrin
Format:	Article
Language:	English
Subjects:	androgen androgen deficiency Androgens - blood Androgens - physiology Androgens - therapeutic use Cells, Cultured Female folliculogenesis Gene Expression Regulation Humans Hyperandrogenism - therapy Infertility, Female - diagnosis Infertility, Female - drug therapy Infertility, Female - metabolism Ovarian Follicle - growth & development Ovary - metabolism PCOS steroidogenesis Steroids - biosynthesis
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description	Ovarian androgen synthesis and regulation are essential to ensure adequate steroidogenesis and folliculogenesis. In primates, there is evidence for a direct impact on the number of small antral follicles and on the process of chronic anovulation. Therefore, serum androgen should be more carefully assessed in infertile women. Accurate measurements of serum androgen are required to better identify patients with androgen excess or deficiency. Medical or surgical interventions are able to decrease ovarian androgen excess and to reduce the risk of hyperstimulation. Conversely, androgen supplementation should be considered in women at risk of low ovarian response to gonadotrophins, related to androgen deficiency. This review supports a specific and broad role of androgen in reproductive physiology.
doi_str_mv	10.1016/S1472-6483(10)61165-0
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subjects	androgen androgen deficiency Androgens - blood Androgens - physiology Androgens - therapeutic use Cells, Cultured Female folliculogenesis Gene Expression Regulation Humans Hyperandrogenism - therapy Infertility, Female - diagnosis Infertility, Female - drug therapy Infertility, Female - metabolism Ovarian Follicle - growth & development Ovary - metabolism PCOS steroidogenesis Steroids - biosynthesis
title	Impact of androgens on fertility – physiological, clinical and therapeutic aspects
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