Can antiemetics really relieve pain?

The analgesic properties of 2 antiemetic agents--metoclopramide and ondansetron--were investigated in studies which showed that metoclopramide may decrease postoperative opioid requirements, but the analgesic effect of ondansetron is controversial. The postoperative effects of metoclopramide and ond...

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Bibliographic Details
Published in:Advances in therapy 2005-07, Vol.22 (4), p.307-312
Main Authors: Derbent, Abdurrahim, Uyar, Mehmet, Demirag, Kubilay, Uyer, Meltem, Kurtoglu, Elvin, Goktay, Aylin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analgesics - therapeutic use
Antiemetics - therapeutic use
Female
Health technology assessment
Humans
Laminectomy
Male
Metoclopramide - therapeutic use
Middle Aged
Ondansetron - therapeutic use
Pain, Postoperative - drug therapy
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Summary:The analgesic properties of 2 antiemetic agents--metoclopramide and ondansetron--were investigated in studies which showed that metoclopramide may decrease postoperative opioid requirements, but the analgesic effect of ondansetron is controversial. The postoperative effects of metoclopramide and ondansetron on pain in patients undergoing laminectomy were evaluated. Forty six patients were randomized into 3 groups: group M, which consisted of 15 patients who received intravenous (IV) metoclopramide 0.5 mg 30 minutes before surgery; group O, which consisted of 16 patients who received ondansetron IV 0.1 mg 30 minutes before surgery; and group C, which consisted of 15 patients who received the same volume of saline IV 30 minutes before surgery. The efficacy and duration of analgesia were assessed using a visual analogue scale (VAS) at 0, 0.5, 1, 3, 6, and 24 hours after surgery. Hemodynamic parameters, additional analgesic requirements, and adverse effects were recorded for the study groups. Diclofenac 75 mg was administered intramuscularly as a rescue analgesic during the postoperative period. VAS scores were lower in the metoclopramide group than in the ondansetron and control groups (P
ISSN:0741-238X
1865-8652
DOI:10.1007/BF02850080