SUV correction for injection errors in FDG-PET examination

Many studies have documented the clinical usefulness of standardized uptake values (SUV) for diagnosis. However, in the event of injection error, accurate measurements cannot be obtained if the radioactivity of fluorodeoxyglucose (FDG) leakage is not subtracted from the administered dosage. Here, a...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nuclear medicine 2007-12, Vol.21 (10), p.607-613
Main Authors: Miyashita, Kouichi, Takahashi, Nobukazu, Oka, Takashi, Asakawa, Shinobu, Lee, Jin, Shizukuishi, Kazuya, Inoue, Tomio
Format: Article
Language:English
Subjects:
Algorithms
Diagnostic Errors - prevention & control
Fluorodeoxyglucose F18 - administration & dosage
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Injections, Intra-Arterial
Medical imaging
Phantoms, Imaging
Positron-Emission Tomography - instrumentation
Positron-Emission Tomography - methods
Radiopharmaceuticals - administration & dosage
Reproducibility of Results
Sensitivity and Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many studies have documented the clinical usefulness of standardized uptake values (SUV) for diagnosis. However, in the event of injection error, accurate measurements cannot be obtained if the radioactivity of fluorodeoxyglucose (FDG) leakage is not subtracted from the administered dosage. Here, a correction formula for radioactivity estimation that takes into account the radioactivity of FDG leakage was derived on the basis of a phantom experiment. Furthermore, to determine whether SUV could be accurately calculated by the correction formula, we performed a volunteer study. Images were displayed by altering the conversion constant from 1.0, 0.1 to 0.01, and the range of correctable counts was verified on the basis of image inversion. To estimate the radioactivity of FDG leakage by imaging, the count of the leakage was measured, converted into a radioactivity concentration using a cross-calibration factor (CCF), and multiplied by volume, as measured by imaging. Three factors that markedly affect count, i.e., count rate performance, partial volume effect and crosstalk, were assessed in phantom studies in order to derive a correction formula. In addition, to clarify the accuracy of the correction formula, we attached to the right elbow. With a conversion constant of 0.1, there was no image inversion at or=15 mm but
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-007-0068-1