Obesity and Risk of Colorectal Cancer: A Meta-analysis of 31 Studies with 70,000 Events

Background: Colorectal cancer is the second most common cause of death and illness in developed countries. Previous reviews have suggested that obesity may be associated with 30% to 60% greater risk of colorectal cancer, but little consideration was given to the possible effect of publication bias o...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-12, Vol.16 (12), p.2533-2547
Main Authors: ANSARY MOGHADDAM, Alireza, WOODWARD, Mark, HUXLEY, Rachel
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body Mass Index
Case-Control Studies
Cohort Studies
colorectal cancer
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Obesity
Obesity - complications
publication bias
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Waist-Hip Ratio
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Summary:Background: Colorectal cancer is the second most common cause of death and illness in developed countries. Previous reviews have suggested that obesity may be associated with 30% to 60% greater risk of colorectal cancer, but little consideration was given to the possible effect of publication bias on the reported association. Methods: Relevant studies were identified through EMBASE and MEDLINE. Studies were included if they had published quantitative estimates of the association between general obesity [defined here as body mass index (BMI) ≥30 kg/m 2 ] and central obesity (measured using waist circumference) and colorectal cancer. Random-effects meta-analyses were done, involving 70,000 cases of incident colorectal cancer from 31 studies, of which 23 were cohort studies and 8 were case-control studies. Results: After pooling and correcting for publication bias, the estimated relative risk of colorectal cancer was 1.19 [95% confidence interval (95% CI), 1.11-1.29], comparing obese (BMI ≥30 kg/m 2 ) with normal weight (BMI
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-07-0708