Treatment of a septic shock due to multiresistant Acinetobacter baumannii with tigecycline in combination

• Published in: Annales françaises d'anesthésie et de réanimation 2007-12, Vol.26 (12), p.1056-1058
• Main Authors: Leclerc, T, Perez, J-P, Debien, B, Clapson, P, Lenoir, B
• Format: Article
• Language: fre
• Subjects: Acinetobacter baumannii; Acinetobacter Infections - complications; Adolescent; Anti-Bacterial Agents - administration & dosage; Anti-Infective Agents - administration & dosage; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Humans; Minocycline - administration & dosage; Minocycline - analogs & derivatives; Penicillanic Acid - administration & dosage; Penicillanic Acid - analogs & derivatives; Piperacillin - administration & dosage; Shock, Septic - drug therapy; Shock, Septic - microbiology; Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage
• ISSN: 1769-6623
• DOI: 10.1016/j.annfar.2007.08.015

We report a case of pulmonary and bloodstream infection due to multiresistant Acinetobacter baumannii six days after a severe trauma. Clinical condition transiently improved following antimicrobial treatment with ticarcillin-clavulanate and rifampicin. However, a septic shock developed on the fourth day due to the emergence of a strain only sensible to cotrimoxazole, colistin and tigecycline. Cure was achieved after a two week treatment with piperacillin-tazobactam, cotrimoxazole and tigecycline. This case shows that combined antimicrobial therapy including tigecycline can be relevant in some severe pulmonary infections due to multiresistant A. baumannii.