Comparison of anterior gastric wall and greater gastric curvature invaginations for weight loss in rats

Many bariatric endoscopic or surgical procedures performed today reduce gastric capacity and/or induce an early sensation of gastric satiety, alone or in combination with a distal enteric intervention. A form of prosthetic wrap of the folded stomach was used in the past for treating obesity with a h...

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Bibliographic Details
Published in:Obesity surgery 2007-10, Vol.17 (10), p.1340-1345
Main Authors: Fusco, Pedro E B, Poggetti, Renato S, Younes, Riad N, Fontes, Belchor, Birolini, Dario
Format: Article
Language:English
Subjects:
Animals
Cardia - surgery
Fundoplication - methods
Gastrointestinal surgery
Male
Obesity
Obesity, Morbid - surgery
Random Allocation
Rats
Rats, Wistar
Rodents
Surgical outcomes
Weight control
Weight Loss
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Summary:Many bariatric endoscopic or surgical procedures performed today reduce gastric capacity and/or induce an early sensation of gastric satiety, alone or in combination with a distal enteric intervention. A form of prosthetic wrap of the folded stomach was used in the past for treating obesity with a high rate of prosthesis-related reintervention. Nissen gastric fundoplication used in the treatment of gastroesophageal reflux disease induces a small but significant weight loss without gastric stapling, partitioning, or prosthesis-related morbidity. We recently reported greater gastric curvature invagination without stapling, partitioning or prosthesis use, for weight loss in rats. We now compare anterior gastric wall and greater gastric curvature invaginations for weight loss. The anterior invagination would be technically easier, should it be tested in humans. 20 rats were randomized in 2 groups. The anterior gastric wall of 10 rats was invaginated in the first group (AGW). The greater gastric curvature of 10 rats was invaginated in the second group (GGC). All animals were weighed weekly for 4 weeks. They were then autopsied on the 28th day. The mean body weight of the GGC group became statistically less than the AGW group at 21 days. The mean weight of the peritesticular fat pad and the mean gastric volume were not statistically different at 28 days (autopsy). Greater gastric curvature invagination significantly reduces body weight compared to anterior gastric wall invagination at 21 days.
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-007-9238-4