Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients

The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB). Plasma protein carbonyl (PCO) concentration as a marker of protein oxidation, plasma thiol (P-SH) and erythrocyte glutathione c...

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Bibliographic Details
Published in:Obesity surgery 2007-10, Vol.17 (10), p.1367-1373
Main Authors: Uzun, Hafize, Konukoglu, Dildar, Gelisgen, Remisa, Zengin, Kagan, Taskin, Mustafa
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Cholesterol, HDL - blood
Erythrocytes - chemistry
Female
Gastrointestinal surgery
Gastroplasty
Glutathione - blood
Homeostasis - physiology
Humans
Insulin resistance
Insulin Resistance - physiology
Male
Middle Aged
Obesity
Obesity, Morbid - metabolism
Obesity, Morbid - physiopathology
Obesity, Morbid - surgery
Oxidative Stress
Plasma
Postoperative Period
Protein Carbonylation - physiology
Proteins
Sulfhydryl Compounds - blood
Surgical outcomes
Weight control
Weight Loss
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Summary:The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB). Plasma protein carbonyl (PCO) concentration as a marker of protein oxidation, plasma thiol (P-SH) and erythrocyte glutathione concentration (GSH, major intracellular thiol), as an antioxidant and metabolic markers, such as Homeostatic Model Assessment - Insulin resistance (HOMA-IR), BMI and plasma lipids were determined in morbidly obese patients (n 22, mean age 34.7 +/- 11 years, BMI 48.4 +/- 6.4 kg/m2) at baseline and 1 and 6 months after operation. Baseline levels in patients were also compared with the levels in age-matched controls (n 20, BMI 21.3 +/- 1.8 kg/m2). Plasma PCO and thiols and erythrocyte GSH concentrations were determined spectrophotometrically. Plasma PCO were significantly higher and plasma and erythrocyte thiol concentrations were significantly lower in morbidly obese patients than in controls (for each comparison, P
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-007-9242-8