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Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients
The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB). Plasma protein carbonyl (PCO) concentration as a marker of protein oxidation, plasma thiol (P-SH) and erythrocyte glutathione c...
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| Published in: | Obesity surgery 2007-10, Vol.17 (10), p.1367-1373 |
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| container_title | Obesity surgery |
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| creator | Uzun, Hafize Konukoglu, Dildar Gelisgen, Remisa Zengin, Kagan Taskin, Mustafa |
| description | The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB).
Plasma protein carbonyl (PCO) concentration as a marker of protein oxidation, plasma thiol (P-SH) and erythrocyte glutathione concentration (GSH, major intracellular thiol), as an antioxidant and metabolic markers, such as Homeostatic Model Assessment - Insulin resistance (HOMA-IR), BMI and plasma lipids were determined in morbidly obese patients (n 22, mean age 34.7 +/- 11 years, BMI 48.4 +/- 6.4 kg/m2) at baseline and 1 and 6 months after operation. Baseline levels in patients were also compared with the levels in age-matched controls (n 20, BMI 21.3 +/- 1.8 kg/m2). Plasma PCO and thiols and erythrocyte GSH concentrations were determined spectrophotometrically.
Plasma PCO were significantly higher and plasma and erythrocyte thiol concentrations were significantly lower in morbidly obese patients than in controls (for each comparison, P |
| doi_str_mv | 10.1007/s11695-007-9242-8 |
| format | article |
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Plasma protein carbonyl (PCO) concentration as a marker of protein oxidation, plasma thiol (P-SH) and erythrocyte glutathione concentration (GSH, major intracellular thiol), as an antioxidant and metabolic markers, such as Homeostatic Model Assessment - Insulin resistance (HOMA-IR), BMI and plasma lipids were determined in morbidly obese patients (n 22, mean age 34.7 +/- 11 years, BMI 48.4 +/- 6.4 kg/m2) at baseline and 1 and 6 months after operation. Baseline levels in patients were also compared with the levels in age-matched controls (n 20, BMI 21.3 +/- 1.8 kg/m2). Plasma PCO and thiols and erythrocyte GSH concentrations were determined spectrophotometrically.
Plasma PCO were significantly higher and plasma and erythrocyte thiol concentrations were significantly lower in morbidly obese patients than in controls (for each comparison, P<0.01). BMI, plasma triglycerides and HOMA-IR were positively correlated with plasma PCO and negatively correlated with plasma P-SH and erythrocyte GSH (for each comparison, P<0.01). Plasma HDL-cholesterol levels were positively correlated with plasma erythrocyte GSH (r = 0.405, P<0.01) and negative correlated with plasma PCO (r = -0.273, P<0.01). One and 6 months after the LAGB operation, total weight loss was 13.2 +/- 6.3 and 35.5 +/- 7.5 kg, respectively. Plasma PCO concentrations were decreased and P-SH and erythrocyte GSH concentrations were elevated following weight loss (for each, P<0.01). Only plasma P-SH levels were restored to the control levels 6 months after LAGB.
Obesity and insulin resistance appear to be associated with plasma protein oxidation and thiol concentrations. Protein and thiol oxidative stress was improved by weight loss after LAGB in the short-term.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-007-9242-8</identifier><identifier>PMID: 18000722</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; Body Mass Index ; Cholesterol, HDL - blood ; Erythrocytes - chemistry ; Female ; Gastrointestinal surgery ; Gastroplasty ; Glutathione - blood ; Homeostasis - physiology ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Male ; Middle Aged ; Obesity ; Obesity, Morbid - metabolism ; Obesity, Morbid - physiopathology ; Obesity, Morbid - surgery ; Oxidative Stress ; Plasma ; Postoperative Period ; Protein Carbonylation - physiology ; Proteins ; Sulfhydryl Compounds - blood ; Surgical outcomes ; Weight control ; Weight Loss</subject><ispartof>Obesity surgery, 2007-10, Vol.17 (10), p.1367-1373</ispartof><rights>Springer Science + Business Media, LLC 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-6ac32e4a6e80c3aa1242ed7dea066eb3a6a22431c546acc4595d09b7309100873</citedby><cites>FETCH-LOGICAL-c326t-6ac32e4a6e80c3aa1242ed7dea066eb3a6a22431c546acc4595d09b7309100873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18000722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uzun, Hafize</creatorcontrib><creatorcontrib>Konukoglu, Dildar</creatorcontrib><creatorcontrib>Gelisgen, Remisa</creatorcontrib><creatorcontrib>Zengin, Kagan</creatorcontrib><creatorcontrib>Taskin, Mustafa</creatorcontrib><title>Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients</title><title>Obesity surgery</title><addtitle>Obes Surg</addtitle><description>The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB).
Plasma protein carbonyl (PCO) concentration as a marker of protein oxidation, plasma thiol (P-SH) and erythrocyte glutathione concentration (GSH, major intracellular thiol), as an antioxidant and metabolic markers, such as Homeostatic Model Assessment - Insulin resistance (HOMA-IR), BMI and plasma lipids were determined in morbidly obese patients (n 22, mean age 34.7 +/- 11 years, BMI 48.4 +/- 6.4 kg/m2) at baseline and 1 and 6 months after operation. Baseline levels in patients were also compared with the levels in age-matched controls (n 20, BMI 21.3 +/- 1.8 kg/m2). Plasma PCO and thiols and erythrocyte GSH concentrations were determined spectrophotometrically.
Plasma PCO were significantly higher and plasma and erythrocyte thiol concentrations were significantly lower in morbidly obese patients than in controls (for each comparison, P<0.01). BMI, plasma triglycerides and HOMA-IR were positively correlated with plasma PCO and negatively correlated with plasma P-SH and erythrocyte GSH (for each comparison, P<0.01). Plasma HDL-cholesterol levels were positively correlated with plasma erythrocyte GSH (r = 0.405, P<0.01) and negative correlated with plasma PCO (r = -0.273, P<0.01). One and 6 months after the LAGB operation, total weight loss was 13.2 +/- 6.3 and 35.5 +/- 7.5 kg, respectively. Plasma PCO concentrations were decreased and P-SH and erythrocyte GSH concentrations were elevated following weight loss (for each, P<0.01). Only plasma P-SH levels were restored to the control levels 6 months after LAGB.
Obesity and insulin resistance appear to be associated with plasma protein oxidation and thiol concentrations. Protein and thiol oxidative stress was improved by weight loss after LAGB in the short-term.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Cholesterol, HDL - blood</subject><subject>Erythrocytes - chemistry</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Gastroplasty</subject><subject>Glutathione - blood</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - metabolism</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - surgery</subject><subject>Oxidative Stress</subject><subject>Plasma</subject><subject>Postoperative Period</subject><subject>Protein Carbonylation - physiology</subject><subject>Proteins</subject><subject>Sulfhydryl Compounds - blood</subject><subject>Surgical outcomes</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpdUcFq3DAQFaEhu0n7Ab0U0UNubkYjr2wdS2jTQKA5JGcxlmcTL7blSN7D_n3k7EKhpzdI7z3mzRPiq4IfCqC6SUoZuynyWFgssajPxFpVUBdQYv1JrMEaKGqLeiUuU9oBoDKIF2KlasgixLV4e-wpDSSnGGbuRukpNmE89JLGVs6vXehlmiOnJBvehsgf77SdOcqeJooh-TB1Xr5QpmVs8n83vshsNYTYdG1_kKHhxHKiueNxTp_F-Zb6xF9OeCWef_96uv1TPPy9u7_9-VB4jWYuDGXkkgzX4DWRygG5rVomMIYbTYYQS638psxUX27spgXbVBpsvk1d6StxffTN0d72nGY3dMlz39PIYZ-csVBVStlM_P4fcRf2ccy7OUSNCBoXN3Uk-Rw5Rd66KXYDxYNT4JYy3LEMt4xLGa7Omm8n430zcPtPcbq-fgccSYW8</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Uzun, Hafize</creator><creator>Konukoglu, Dildar</creator><creator>Gelisgen, Remisa</creator><creator>Zengin, Kagan</creator><creator>Taskin, Mustafa</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients</title><author>Uzun, Hafize ; Konukoglu, Dildar ; Gelisgen, Remisa ; Zengin, Kagan ; Taskin, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-6ac32e4a6e80c3aa1242ed7dea066eb3a6a22431c546acc4595d09b7309100873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Cholesterol, HDL - blood</topic><topic>Erythrocytes - chemistry</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Gastroplasty</topic><topic>Glutathione - blood</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - metabolism</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - surgery</topic><topic>Oxidative Stress</topic><topic>Plasma</topic><topic>Postoperative Period</topic><topic>Protein Carbonylation - physiology</topic><topic>Proteins</topic><topic>Sulfhydryl Compounds - blood</topic><topic>Surgical outcomes</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uzun, Hafize</creatorcontrib><creatorcontrib>Konukoglu, Dildar</creatorcontrib><creatorcontrib>Gelisgen, Remisa</creatorcontrib><creatorcontrib>Zengin, Kagan</creatorcontrib><creatorcontrib>Taskin, Mustafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uzun, Hafize</au><au>Konukoglu, Dildar</au><au>Gelisgen, Remisa</au><au>Zengin, Kagan</au><au>Taskin, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients</atitle><jtitle>Obesity surgery</jtitle><addtitle>Obes Surg</addtitle><date>2007-10</date><risdate>2007</risdate><volume>17</volume><issue>10</issue><spage>1367</spage><epage>1373</epage><pages>1367-1373</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB).
Plasma protein carbonyl (PCO) concentration as a marker of protein oxidation, plasma thiol (P-SH) and erythrocyte glutathione concentration (GSH, major intracellular thiol), as an antioxidant and metabolic markers, such as Homeostatic Model Assessment - Insulin resistance (HOMA-IR), BMI and plasma lipids were determined in morbidly obese patients (n 22, mean age 34.7 +/- 11 years, BMI 48.4 +/- 6.4 kg/m2) at baseline and 1 and 6 months after operation. Baseline levels in patients were also compared with the levels in age-matched controls (n 20, BMI 21.3 +/- 1.8 kg/m2). Plasma PCO and thiols and erythrocyte GSH concentrations were determined spectrophotometrically.
Plasma PCO were significantly higher and plasma and erythrocyte thiol concentrations were significantly lower in morbidly obese patients than in controls (for each comparison, P<0.01). BMI, plasma triglycerides and HOMA-IR were positively correlated with plasma PCO and negatively correlated with plasma P-SH and erythrocyte GSH (for each comparison, P<0.01). Plasma HDL-cholesterol levels were positively correlated with plasma erythrocyte GSH (r = 0.405, P<0.01) and negative correlated with plasma PCO (r = -0.273, P<0.01). One and 6 months after the LAGB operation, total weight loss was 13.2 +/- 6.3 and 35.5 +/- 7.5 kg, respectively. Plasma PCO concentrations were decreased and P-SH and erythrocyte GSH concentrations were elevated following weight loss (for each, P<0.01). Only plasma P-SH levels were restored to the control levels 6 months after LAGB.
Obesity and insulin resistance appear to be associated with plasma protein oxidation and thiol concentrations. Protein and thiol oxidative stress was improved by weight loss after LAGB in the short-term.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>18000722</pmid><doi>10.1007/s11695-007-9242-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Obesity surgery, 2007-10, Vol.17 (10), p.1367-1373 |
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| source | Springer Nature |
| subjects | Adult Body Mass Index Cholesterol, HDL - blood Erythrocytes - chemistry Female Gastrointestinal surgery Gastroplasty Glutathione - blood Homeostasis - physiology Humans Insulin resistance Insulin Resistance - physiology Male Middle Aged Obesity Obesity, Morbid - metabolism Obesity, Morbid - physiopathology Obesity, Morbid - surgery Oxidative Stress Plasma Postoperative Period Protein Carbonylation - physiology Proteins Sulfhydryl Compounds - blood Surgical outcomes Weight control Weight Loss |
| title | Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients |
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