Hyperglycaemia and insulinopenia in a neonate with cystic fibrosis

Abnormal glucose tolerance is a frequent late complication of cystic fibrosis (CF), but the prevalence of CF-related diabetes mellitus (CFRD) in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinopenia is the primary cause of abnormal...

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Bibliographic Details
Published in:Acta pædiatrica (Oslo) 2005-12, Vol.94 (12), p.1837-1840
Main Authors: SIAHANIDOU, Tania, MANDYLA, Helen, DOUDOUNAKIS, Stavros, ANAGNOSTAKIS, Dimitris
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cystic Fibrosis - complications
Cystic Fibrosis - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Errors of metabolism
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
General aspects
Glucose Intolerance - etiology
Glucose Intolerance - physiopathology
Glucose Tolerance Test
Humans
Hyperglycemia - etiology
Hyperglycemia - physiopathology
Infant, Newborn
Insulin - blood
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
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Summary:Abnormal glucose tolerance is a frequent late complication of cystic fibrosis (CF), but the prevalence of CF-related diabetes mellitus (CFRD) in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinopenia is the primary cause of abnormal glucose tolerance/CFRD, but it is unknown whether it may begin in the neonatal period. We describe a case of a neonate with CF who presented with hyperglycaemia in the diabetic range and marked insulinopenia. Insulinopenia and impaired glucose tolerance were permanent findings at 6 and 15 mo of age. This case suggests that abnormal glucose tolerance/diabetes may occur much earlier in the course of CF, even during neonatal age. Careful follow-up and further studies in CF infants could reveal that the real incidence of glucose intolerance and diabetes in this age group has been underestimated.
ISSN:0803-5253
1651-2227
DOI:10.1080/08035250510040241